2022年07月12日 02:23  点击：[]

杨俊杰

个人简介

杨俊杰，博士，教授。主要从事与精准诊疗相关的基因组学和微生物组学研究。2014年起，加入山东省泰山学者海外特聘专家科研创新团队，并在山东省儿童微生物组学研究中心、青岛市人类微生物组研究中心及山东省大健康精准医疗产业技术研究院开展人体微生物组研究工作。主要成果包括绘制了山东地区健康人群和多种疾病人群的菌群特征图谱，构建了区域性、多疾病类型、多样本类型的菌群研究样本库、菌株库和数据库，目前数据库拥有一万余例临床样本的高通量测序数据。同时开展了以膳食纤维为主的功能性食品干预糖尿病、高血脂等慢性病的临床研究。主持山东省自然科学基金项目1项，参与山东省重点研发计划项目1项及山东省重大科技创新工程项目1项。授权国家专利己计算机软件著作权6项。出版学术专著1部。近三年发表SCI学术论文21篇。代表性论文发表在mSystems, 2020（Q1，IF:6.633）,Pharmacological Research, 2020 (Q1,IF:5.893),Genomics，Proteomics & Bioinformatics，2019(Q1,IF:7.051)，Frontiers in Microbiology，2019 (Q1,IF:4.235),Frontiers in Oncology，2018 (Q2,IF:4.848)，Microbiome, 2018(Q1,IF:10.465）等。

主要研究方向

微生物组与肿瘤发生：重点研究非吸烟女性肺癌患者遗传因素和微生物组因素参与疾病发生发展的潜在机制；多组学网络关联和拓扑特征分析，发现并验证特异性标志物。

主持和参与课题

1）山东省自然科学基金项目，2015ZRB01226，口腔菌群结构动态变化与胃癌发生发展相关性的研究，2015/08-2018/08，3万元，已结题，主持。

2）山东省重点研发计划项目，2016YYSP009，以海洋生物资源为原料的高附加值医用食品制备及检测关键技术研究，2016/11-2018/12，100万元，已结题，参与 。

3）山东省重大科技创新工程项目，2018CXGC1219，性早熟儿童肠道菌群精准评估及肠道微生态个性化干预体系，2018.08-2021.08，100万元，在研，参与 。

发表科研论文

1) Changying Zhao^#, Zefeng Wei^#,Junjie Yang^#, Jiaming Zhang, Chunna Yu, Aijun Yang, Min Zhang, Lin Zhang, Ye Wang, Xiaofeng Mu, Xueyuan Heng, Huijun Yang, Zhongtao Gai, Xuenan Wang, Lei Zhang^*. Characterization of vaginal microbiome in women with infertility and its potential correlation with hormone stimulation during IVF surgery.mSystems, 2020, 5(4): e00450-20.

2）Ying Wang^#, Ning Li^#,Jun-Jie Yang^#, Dong-Mei Zhao, Bin Chen5, Guo-Qing Zhang, Shuo Chen, Rui-Fang Cao, Han Yu, Chang-Ying Zhao, Lu Zhao, Yong-Sheng Ge, Yi Liu, Le-Hai Zhang, Wei Hu, Lei Zhang^*, Zhong-Tao Gai^*.Probiotics and fructo-oligosaccharide intervention modulate the microbiota-gut brain axis to improve autism spectrum reducing also the hyper-serotonergic state and the dopamine metabolism disorder.Pharmacological Research, 2020, 157:104784.

3)Junjie Yang^#, Jiaming Zhang^#, Changying Zhao^#, Zhongtao Gai, Xiaofeng Mu, Ye Wang, Chunling Zhang, Zhenzhen Su, Lihe Gao, Dequan Zhu, Zhiwen Zuo, Xueyuan Heng^*, Lei Zhang^*. Blood loss leads to increase in relative abundance of opportunistic pathogens in the gut microbiome of rabbits.Current Microbiology, 2020, 77: 415-424.

4) Huijun Yang^#, Jiaming Zhang^#, Zhiwei Xue, Changying Zhao, Lijun Lei, Yan Wen, Yunling Dong,Junjie Yang^*, Lei Zhang^*. Potential Pathogenic Bacteria in Seminal Microbiota of Patients with Different Types of Dysspermatism.Scientific Reports, 2020, 10:6876.

5) Bin Chen^#, Zhe Wang^#, Jingwen Wang, Xinhuan Su,Junjie Yang, Qunye Zhang^*, Lei Zhang^*. The oral microbiome profile and biomarker in Chinese type 2diabetes mellitus patients.Endocrine, 2020, 68(3):564-572.

6) Weizheng Li, Kyle Stirling,Junjie Yang, Lei Zhang^*. Gut microbiota and diabetes: From correlation tocausality and mechanism.World Journal of Diabetes, 2020, 11(7):293-308.

7）Li Ning^#,Junjie Yang^#,Jiaming Zhang, Cheng Liang, Ying Wang, Bin Chen, Changying Zhao, Jingwen Wang, Guangye Zhang, Dongmei Zhao, Yi Liu, Lehai Zhang, Jun Yang, Guimei Li^*, Zhongtao Gai^*, Lei Zhang^*, Guoping Zhao.Correlation of Gut Microbiome Between ASD Children and Mothers and Potential Biomarkers for Risk Assessment.Genomics, Proteomics & Bioinformatics, 2019, 17(1):26-28.

8）Zhen Zhang^#,Junjie Yang^#, Qiang Feng, Bin Chen3, Meihui Li,Cheng Liang, Mingyu Li, Zhihui Li, Qin Xu, Lei Zhang^*, Wantao Chen^*.Compositional and Functional Analysis of the Microbiome in Tissue and Saliva of Oral Squamous Cell Carcinoma.Frontiers in Microbiology, 2019, 10: 1439.

9) Fanghua Zhang^#, Meng Wang^#,Junjie Yang^#, Qian Xu, Cheng Liang, Bin Chen, Jiaming Zhang, Ying Yang, Huiling Wang, Yongfang Shang, Ye Wang, Xiaofeng Mu, Dequan Zhu, Chunling Zhang, Minxiu Yao^*, Lei Zhang^*. Response of gut microbiota in type 2 diabetes to hypoglycemic agents.Endocrine, 2019, 66(3):485-493.

10) Zhaogang Dong^#, Bin Chen^#, Hongwei Pan, Ding Wang, Min Liu, Yongmei Yang, Mingjin Zou,Junjie Yang, Ke Xiao, Rui Zhao, Xin Zheng, Lei Zhang^*, Yi Zhang^*. Detection of Microbial 16S rRNA Gene in the Serum of Patients With Gastric Cancer.Frontiers in Oncology，2019, 9: 608.

11）Jiaming Zhang^#, Fanghua Zhang^#, Changying Zhao, Qian Xu, Cheng Liang, Ying Yang, Huiling Wang, Yongfang Shang, Ye Wang, Xiaofeng Mu, Dequan Zhu, Chunling Zhang,Junjie Yang^*, Minxiu Yao^*, Lei Zhang^*. Dysbiosis of the gut microbiome is associated with thyroid cancer and thyroid nodules and correlated with clinical index of thyroid function.Endocrine,2019, 64: 564-574.

12) Xiaofeng Mu^#, Changying Zhao^#,Junjie Yang, Xiaofang Wei, Jiaming Zhang, Cheng Liang, Zhongtao Gai, Chunling Zhang, Dequan Zhu, Ye Wang^*, Lei Zhang^*. Group B Streptococcus colonization induces Prevotella and Megasphaera abundance-featured vaginal microbiome compositional change in non-pregnant women.Peer J,2019, 7: e7474.

13) Lu Yang^#, Jiaming Zhang, Junjie Xu, Xuxia Wei,Junjie Yang,Yi Liu, Hua Li, Changying Zhao, Ying Wang, Lei Zhang^*, Zhongtao Gai^*. Helicobacter pylori infection aggravates dysbiosis of gut microbiome in children with gastritis.Frontiers in Cellular and Infection Microbiology, 2019, 9:375.

14)Meng Wang^#,Junjie Yang^#, Zhongtao Gai, Shengnan Huo, Jianhua Zhu, Jun Li, Ranran Wang, Sheng Xing, Guosheng Shi, Feng Shi^*, Lei Zhang^*. Comparison between digital PCR and real-time PCR in detection of Salmonella typhimurium in milk.International Journal of Food Microbiology, 2018, 266: 251-256.

15）XueYing Zhang^#, Gansukh Sukhchuluun^#, TingBei Bo^#, QingSheng Chi,JunJie Yang, Bin Chen, Lei Zhang^*,DeHua Wang^*, Huddling remodels gut microbiota to reduce energy requirements in a small mammal species during cold exposure,Microbiome, 2018, 6: 103.

16）Junjie Yang^#, Xiaofeng Mu, Ye Wang, Dequan Zhu, Jiaming Zhang, Cheng Liang, Bin Chen, Jingwen Wang,Changying Zhao, Zhiwen Zuo, Xueyuan Heng^*, Chunling Zhang^*, Lei Zhang^*. Dysbiosis of the salivary microbiome is associated with non-smoking female lung cancer and correlated with immunocytochemistry markers.Frontiers in Oncology, 2018, 8: 520.

17）Shen Meng^#, Bin Chen^#,Junjie Yang^#,Jingwen Wang, Dequan Zhu, Qingsong Meng^*,Lei Zhang^*. Study of Microbiomes in Aseptically Collected Samples of Human Breast Tissue Using Needle Biopsy and the Potential Role of in situ Tissue Microbiomes for Promoting Malignancy.Frontiers in Oncology, 2018, 8:318.

18）Bin Chen^#, Jingwen Wang^#, Ying Wang, Jiaming Zhang, Changying Zhao, Nan Shen,Junjie Yang^*, Zhongtao Gai^*, Lei Zhang^*. Oral microbiota dysbiosis and its association with Henoch-Schönlein Purpura in children.International Immunopharmacology, 2018, 65: 295-302.

19）Bin Chen^#, Yan Zhao^#, Shufeng Li, Lanxiu Yang, Haiying Wang, Tao Wang, Bin Shi,Junjie Yang^*,Lei Zhang^*. Variations in oral microbiome profiles in rheumatoid arthritis and osteoarthritis and potential biomarkers for arthritis screening.Scientific Reports, 2018, 8: 17126.

20）Yan Zhao^#, Bin Chen^#, Shufeng Li, Lanxiu Yang, Dequan Zhu, Ye Wang, Haiying Wang, Tao Wang, Bin Shi, Zhongtao Gai, Jun Yang, Xueyuan Heng,Junjie Yang^*,Lei Zhang^*. Detection and characterization of bacterial nucleic acids in culture-negative synovial tissue and fluid samples from rheumatoid arthritis or osteoarthritis patients.Scientific Reports, 2018, 8:14305.

21）Xingcui Wang, Lei Zhang, Ying Wang, Xuemei Liu, Hongxia Zhang, Yi Liu, Nan Shen,Junjie Yang^*,Zhongtao Gai^*. Gut microbiota dysbiosis is associated with Henoch-Schönlein Purpura in children,International Immunopharmacology, 2018, 58: 1–8.

授权国家专利及计算机软件著作权

1） 国家发明专利《肠道及口腔菌群多样性及差异性的分析方法》，专利号ZL 201710019639.8，已授权。

2）国家发明专利《植物提取物及其制备方法》，专利号ZL201710019638.3，已授权。

3）实用新型专利《唾液采集设备》，专利号ZL201420553632.6，已授权。

4）实用新型专利《口腔样本采集设备》，专利号ZL 201520118249.2，已授权。

5）实用新型专利《一种粪便试样采集装置》，专利号ZL 201721454243.8，已授权。

6）计算机软件著作权，《HC-BC120血培养仪协处理器控制软件》登记号2020SR0848505。

 

学术专著译著

1） 张磊、杨俊杰、盖中涛，《欢迎走进微生物组》 北京：清华大学出版社，ISBN：978-7-302-49099-9。

获奖情况

1）2007.04 荣获2006-2007第一学期“优秀教案”

2）2007.11 荣获第二届计算机辅助教学课件比赛“二等奖”

3）2011.12荣获齐鲁师范学院第二届说课比赛“二等奖”

4）2011.10 荣获齐鲁师范学院“我最喜爱的老师”荣誉称号

5）2012.06 荣获齐鲁师范学院第五届青年教师课堂教学大奖赛“三等奖”

6）2012.10荣获齐鲁师范学院教育工会系统优秀调研成果评比“三等奖”

7）2017.08 荣获齐鲁师范学院科研成果转化为教学资源专项奖“三等奖”

8）2019.10 荣获齐鲁师范学院2019年度校级优秀科研成果奖“二等奖”